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Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11

  • Jun-Young Kim, Srikanta Sahu, Yin-Hoe Yau, Xu Wang
  • Dec 25, 2015
  • 1 min read

Bacterial biofilms are responsible for a wide range of persistent infections. In the clinic, diagnosis of biofilm-associated infections relies heavily on culturing methods which fail to detect non-culturable bacteria. Identification of novel fluorescent probes for biofilm imaging will greatly facilitate diagnosis of pathogenic bacterial infection. Herein, we report a novel fluorescent probe, CDy11 (Compound of Designation Yellow 11), which targets amyloid in the Pseudomonas aeruginosa biofilm matrix through a Diversity Oriented Fluorescent Library Approach (DOFLA). CDy11 was further demonstrated for in vivo imaging of P. aeruginosa in implant and corneal infection mice models.


 
 
 

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Dr. Yang Liang

Singapore Centre on Environmental Life Sciences Engineering (SCELSE)
Nanyang Technological University
Nanyang Drive 60

SBS-01n-27, Singapore 637551
Web: www.scelse.sg 

​Email : yangliang@ntu.edu.sg

Nanyang Assistant Professor
Alexander von Humboldt Fellow
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